first_imgLittle Angels Special School in Letterkenny has obtained a leaked copy of the trailer for the new Star Wars movie filmed in Donegal this week.This is a world exclusive and Donegal Daily are the first news outlet to see it. Congrats to all the pupils who ALL played their part in this wonderful production!Simply click on the video to play.DDTV: DONEGAL SCHOOL GETS SNEAK PREVIEW OF STAR WARS FILMING! was last modified: May 20th, 2016 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:donegalLittle Angels Special SchoolStar Warslast_img read more

Half-time: Sheffield Wednesday 1 QPR 0

first_imgGary Hooper’s goal five minutes before half-time means QPR trail at the interval at Hillsborough.David Jones’ scuffed shot ricocheted into the path of Hooper and the striker, played onside by Niko Hamalainen, slotted past Alex Smithies.Sheffield Wednesday had gone close when Fernando Forestieri headed a 21st-minute corner towards Daniel Pudil, who volleyed against the bar from close range.Tjaronn Chery had a couple of early efforts for Rangers, both of which were saved by stand-in keeper Cameron Dawson, who was given his full debut for the Owls after Kieran Westwood was ruled out with a back injury.Conor Washington did find the net after being found by Ben Gladwin’s cross but the goal was rightly disallowed for a clear foul on Jack Hunt.Hamalainen and the fit-again Gladwin started in place of the injured Joel Lynch and Jordan Cousins respectively.Gladwin has been booked, as has fellow R’s midfielder Ariel Borysiuk.QPR: Smithies, Perch, Onuoha, Caulker, Hamalainen, Borysiuk, Luongo, Gladwin, Chery, Washington, Sylla.Subs: Ingram, Wszolek, Polter, El Khayati, Shodipo, Henry, Kakay.Click here for the latest QPR transfer gossipClick here for today’s QPR quiz   Ads by Revcontent Trending Articles Urologists: Men, Forget the Blue Pill! This “Destroys” ED x ‘Genius Pill’ Used By Rich Americans Now Available In Netherlands! x One Cup of This (Before Bed) Burns Belly Fat Like Crazy! x Men, You Don’t Need the Blue Pill if You Do This x What She Did to Lose Weight Stuns Doctors: Do This Daily Before Bed! x Drink This Before Bed, Watch Your Body Fat Melt Like Crazy x Follow West London Sport on TwitterFind us on Facebooklast_img read more

Rotary Clock Discovered in Bacteria

first_imgWhat could be more mechanical than a mechanical clock?  A biochemist has discovered one in the simplest of organisms, one-celled cyanobacteria.  Examining the three complex protein components of its circadian clock, he thinks he has hit on a model that explains its structure and function: it rotates to keep time.  Though it keeps good time, this clock is only about 10 billionths of a meter tall.    Scientists have known the parts of the cyanobacterial clock.  They are named KaiA, KaiB, and KaiC.  Jimin Wang of the Department of Molecular Biophysics and Biochemistry at Yale, publishing in Structure,1 has found an elegant solution to how the parts interact.  He was inspired by the similarity of these parts to those in ATP synthase (see 04/30/2005 entry), a universal enzyme known as a rotary motor.  Though structurally different, the Kai proteins appear to operate as another rotary motor – this time, a clock.    We learned last time (see 09/15/2004 entry) that the parts interact in some way in sync with the diurnal cycle, but the mechanism was still a “black box.”  Wang found that the KaiC part, a six-sided hexagonal cylinder, has a central cavity where the KaiA part can fit when it undergoes an “activation” that changes its shape, somewhat like unfolding scissors.  Like a key, it fits into the central shaft and turns.  The KaiB part, like a wing nut, fastens on KaiB at the bottom of the KaiC carousel.  For every 120° turn of the spindle, phosphate groups attach to the outside of the carousel, till KaiC is fully saturated, or phosphorylated.  This apparently happens to multiple Kai complexes during the night.    How does this keep time?  When unphosphorylated, KaiC affects the expression of genes.  During the night, when complexed with the other two parts, it is repressed from acting, effectively shutting down the cell for the night.  Apparently many of these complexes form and dissociate each cycle.  As the complexes break up in the morning, expression resumes, and the cell wakes up.  When KaiC separates from the other parts, it is destroyed, stopping its repression of genes and stimulating the creation of more KaiC.  “In summary,” he says, “the Kai complexes are a rotary clock for phosphorylation, which sets the destruction pace of the night-dominant Kai complexes and timely releases KaiA.”  The system sets up a day-night oscillation feedback loop that allows the bacterium keep in sync with the time of day.    Wang shares the surprise that a bacterium could have a clock that persists longer than the cell-division cycle.  This means that the act of cell division does not break the clock:The discovery of a bacterial clock unexpectedly breaks the paradigm of biological clocks, because rapid cell division and chromosome duplication in bacteria occur within one circadian period (Kondo et al., 1994 and Kondo et al., 1997).  In fact, these cyanobacterial oscillators in individual cells have a strong temporal stability with a correlation time of several months.    (Emphasis added in all quotes.)Wang’s article has elegant diagrams of the parts and how they precisely fit together.  In his model, the KaiC carousel resembles the hexagonal F1 motor of ATP synthase, and the KaiA “key” that fits into the central shaft resembles the camshaft.  KaiB, in turn, acts like the inhibitor in ATP synthase.  “The close relationship between the two systems may well extend beyond their structural similarity,” he suggests in conclusion, “because the rhythmic photosynthesis-dependent ATP generation is an important process under the Kai circadian regulation.”1Jimin Wang, “Recent Cyanobacterial Kai Protein Structures Suggest a Rotary Clock,” Structure, Volume 13, Issue 5, May 2005, Pages 735-741, doi:10.1016/j.str.2005.02.011.Need we tell readers what we are about to say?  “There is no mention of evolution in this paper.”  The inverse law of Darwinese stands: the more detailed the discussion of cellular complexity, the less the tendency to mention evolution.    This is wonderful stuff.  The cell is alive with wheels, gears, motors, monorails, winches, ratchets and clocks.  Paley would be pleased.(Visited 9 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Airline group slams inconsistent electronics ban

first_imgThe US and UK governments have been urged to find an alternative to the recent ban on large electronic devices in aircraft cabins and slammed for the “woefully lacking’’ way in which the measures were introduced.The comments from International Air transport Association director general Alexandre de Juniac came in a highly critical speech in Montreal which also questioned the effectiveness of the measures to ban devices such as laptops and tablets in carry-on baggage on some flights to the two countries from North Africa and the Middle East.“The current measures are not an acceptable long-term solution to whatever threat they are trying to mitigate. Even in the short term it is difficult to understand their effectiveness,’’ de Juniac said.“And the commercial distortions they create are severe. We call on governments to work with the industry to find a way to keep flying secure without separating passengers from their personal electronics.’’The IATA boss said passengers and member airlines were asking valid questions such as why the US and UK did not have a common list of airports, referring to a decision by the UK not to follow the US move to include Gulf carriers Etihad, Qatar and Emirates.They were also wondering how laptops could be secure on some flights but not others, including flights departing from the same airport.“And surely there must be a way to screen electronic equipment effectively?’’ he said. “The current situation is not acceptable and will not maintain the all-important confidence of the industry or of travelers. We must find a better way. And Governments must act quickly.’’There was also frustration about the hasty way in which the ban, which became public only after airlines tweeted about it, was implemented.De Juniac described the way in which the measures were introduced as “woefully lacking” with no prior consultation with the industry and little coordination by governments.He renewed IATA’s long-standing call for better information sharing and coordination on security measures among governments and with the industry.Airlines did not want access to state secrets but could help deliver better results if they understood the outcomes governments wanted, he said.“While governments have the primary responsibility for security, we share the priority of keeping passengers, crew and aircraft secure,’’ he said. “To do that effectively intelligence is king. And it needs to be shared amongst governments and with the industry. It’s the only way to stop terrorists before they get near an airport, let alone aircraft.’’IATA has been pushing governments to follow through on a UN Security Council resolution calling on the International Civil Aviation organisation to develop a global aviation security plan.The “very wide gaps’’ in the recent measures taken by governments had highlighted the need for such a plan, de Juniac said.last_img read more

Huddle Up: Dana-Style

first_imguspw 6676632 2Photo Attribution: US PresswireThe good folks at the Smoking Musket join me to talk Dana, WVU’s defense, and what they love about the Big 12. Enjoy!1. What has been the big difference between the hot start and the three-game slide?For one thing, I think we hit a little bit of a wall in terms of the competition gauntlet. In the Big East, you maybe had 1-2 games a year against Top 25 teams. This year, every team in the conference other than Kansas has been ranked at some point in the season. We’re not very deep, especially on defense, and I think the grueling schedule has caught up with us a little bit. But honestly the biggest issue is we lost our mojo. We were flying high after the Texas win, and then got punched in the mouth in Lubbock. I think that stunned our guys, and we haven’t had the mental toughness to bounce back. There are rumors swirling about team chemistry and whatnot, but those are always out there when teams struggle. I just think it’s a confidence issue.2. Everybody knows about Tavon Austin and Geno Smith, but who on WVU’s defense should worry Cowboy fans?Hahahahahahahaha!  Maybe one of the refs will accidentally get in somebody’s way? Or the turf monster might jump up and trip someone as they’re running a corner route? Those are about the two biggest concerns for opposing offenses, at least as far as I’ve been able to tell.Although, there are a few youngsters out there who have shown promise, like safety Karl Joseph, who has been known to lay the wood if and when he actually gets in the proper coverage. And redshirt freshman linebacker Isaiah Bruce is one of the team’s top tacklers and one of the biggest reasons the team has been stout against the run. The other guy plugging up running lanes is nose tackle Shaq Rowell, who has been solid for us this season.3. 1-10, how good of a job do you feel like Dana is doing in year two?I’d go with about a 5. The way the season has gone, though, it’s hard to get a read. Are we just going through a rough stretch or is something seriously wrong within the program?If we can right the ship and finish 8-4, I don’t think too many people will be calling for his head.  But if we slide to 6-6 after starting 5-0 and being ranked (probably unreasonably) in the top 5, that’s a bit concerning.4. Has the transition to the Big 12 been easier than you thought it would be, tougher than you thought, or about how you thought it would be?We knew we would have our hands full, and most folks predicted 9-3 or 10-2 records. When we raced out to that fast start, some of us got hopeful and started dreaming of bigger things despite the defensive struggles. The thing nobody predicted was the sudden disappearance of the offense, and I don’t think that’s attributable to the change in conferences at all.I could have seen us lose a game 48-42 and not been too surprised by it. But to only score 7, 7, and 17 meaningful offensive points in a three game stretch is perplexing to say the least. The thing I’m most impressed about with Big 12 offenses is how quarterbacks are so much more developed. In the Big East, you could count on a couple misfires a game to help stall drives. In the Big 12, you have to go make a play.Otherwise, the fans and the teams we’ve encountered so far have been nothing short of fantastic.  That’s been the part that has made being a fan in the Big 12 so much fun.5. Predictions for Saturday?With the caveat that I’m a perpetual WVU optimist homer, I keep thinking the Mountaineers have to right the ship at some point. They simply can’t stay in an offensive funk for the rest of the year, and I actually saw some improvement out of the defense last week.It doesn’t hurt that we’re decent against the run and Oklahoma State’s quarterback situation is unsettled. I’ve seen a few other folks pick WVU in the upset this week, and I’m going to agree with them and take the Mounties 42-31. Now that I’ve said that, we’ll probably get blown out by 3 touchdowns.If you’re looking for the comments section, it has moved to our forum, The Chamber. You can go there to comment and holler about these articles, specifically in these threads. You can register for a free account right here and will need one to comment.If you’re wondering why we decided to do this, we wrote about that here. Thank you and cheers!last_img read more